Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1744 | 1744-30522 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I84V, L90M | L33LF | L10I, T12A, I13V, K20KM, L63P, I64V, I72V, Q92R |
| >1744-30522| codons 4-99 TLWQRPIVAVKIGGQLMEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVRQYDQIP VEICGHKAVGTVLVGPTPVNVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219E | K103N, Y188L | V60VI, A98S, K122E, D123E, I135V, E138A, G196E, T200I, I202V, L228R, V245M |
| >1744-30522| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSVPLDEEFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIEQHRIKVEELRQHLLRWGFFTP DEKHQKEPPFRWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |