Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1743 | 1743-30515 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F | I13V, K20MR, E35D, M36I, N37D, R41RK, R57RK, L63P, A71AV, L89IM, I93IL |
| >1743-30515| codons 4-99 TLWQRPFVTVKIGGQLREALLDTGADDTVLEDIDLPGKWKPKIVGGIGGFVKVKQYDQIP IEICGHKVIGTVLVGPTPVNVIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219R | K101P, K103S | T39DE, E44D, V118I, K122E, T200TA, E203K, Q207QE, H208Y, R211K, K223Q, V245K |
| >1743-30515| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLPKSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYIDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP DRKHQQEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |