Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1140 | 1140-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R | T215TI, K219E | K103NS, Y181C | T39A, V60I, T69N, K102Q, K122E, Q174R, D177E, I178M, V179VI, G196GEKR, T200A, Q207E, R211RK, F214L, L228H |
| >1140-30318| codons 38-247 CAEMEKEGKISKIGPENPYNTPIFAIKKKDSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKQSKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPEMIICQYMDDLYVGSDLEIRQHRAKIEELREHLLKWGLITP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, L90M | V11I, L33F, Q58E | L10I, I13V, L63P, A71V, V77I, I93L |
| >1140-30318| codons 4-99 TLWQRPIITVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFMKVREYDQIP IEICGHKVIGTVVIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |