Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1433 | 1433-30226 | Unknown | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54LV, V82VA, I84IV, L90M | L10F, G73GAST | T12TP, I13IV, K20I, M36MI, N37ND, K55KR, D60DE, I62V, L63P, I64IV, A71AT, I72IT, T74TS, V77VI |
| >1433-30226| codons 4-99 TLWQRPFVPVKIGGQLIEALLDTGADDTVLEEIDLPGRWKPKIIGGIGGFVRVRQYEQVP VEICGHKTTTSVLIGPTPANVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, K65KR, Y115YF, Q151KM, L210SW | A62AV, V75VI, F77FL, F116FY, T215DV, K219KQ | K101AP, Y181YC, G190GA | K64KR, S68SR, K102KQ, L109LM, V118VI, K122E, I135T, S162SC, E169ED, K173KN, I202IV, R211K, F214FL, H221HY | D113Y |
| >1433-30226| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIRRKDRTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLPQKKSVTVMDVGYAFYSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQCSMTKILDPFRNQNPDIVICQYMDDLYVASDLEIGQHRTKVEELRQHLWKWGLVTP DQKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |