Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1138 | 1138-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, L90M | K43T, G73GS, T74TP, N88D | L10LR, R57K, L63P, C67CW, A71AV, V77I, I93L |
| >1138-30528| codons 4-99 TLWQRPRVTIKIGGQLKEALLDTGADNTVLEEMNLPGRWTPKMIGGIGGFLKVKQYDQIP IEIWGHKVISPVLIGPTPVNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | Y188L | K43N, E44D, V60I, K102R, V118I, D177E, I178M, G196E, E203EK, R211E, K223Q, V245K |
| >1138-30528| codons 38-247 CTELENDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKRKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVIYQYMDDLLVGSDLEIEQHRTKIKELRQHLWEWGFYTP DRKHQQEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |