Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1136 | 1136-30516 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | Y181YC, G190GA | K101H | E44D, K64H, V118I, D123E, I135IT, S162C, I195K, G196E, E203K, Q207E, H208Y, R211K, K223Q | I63IK |
| >1136-30516| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAKHKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVICQYMDDLYVASDLEKEQHRTKIKELREYLWKWGFYTP DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L90M | N88ND | L10I, I15V, E35D, M36I, N37E, L63P, K70R, I85V, Q92K |
| >1136-30516| codons 4-99 TLWQRPIVTIKVGGQLKEALLDTGADDTVLEDIELPGRWKPKLIGGIGGFIKVRQYDQIP IEICGHRAIGTVLVGPTPVNIVGRDLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |