Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1128 | 1128-30311 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L33F, K43T, T74P | L10I, I13V, K20R, E35D, M36I, N37D, I62IV, L63P, A71V, I93L |
| >1128-30311| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGRWTPKLIGGIGGFVKVRQYDQVP IEICGHKVIGPVLVGPTPANVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | K43E, E44A, V106I, V118I, K122E, S162Y, V179I, E203EK, E204Q, Q207E, H208Y, K223Q, L228R | L246R |
| >1128-30311| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIIIYQYMDDLYVGSDLEIGQHRTKIKQLREYLWRWGFYTP DRKHQQEPPFRWMGYELHPDKWTVQPIVRP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |