Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2080 | 2080-30616 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, I84V | L10V, K20R, M36I, R41K, L63P, I93L |
| >2080-30616| codons 4-99 TLWQRPVVTIKIGGQLREALLDTGADDTVLEEINLPGKWKPKIIGGIGGFIKVRQYDQIP IEICGHKAIGTVLVGPTPTNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Q151M, M184V | A62V, K70KNT, F116Y | Y181C, G190A | T69S, K122E, D123E, S162A, F214L |
| >2080-30616| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSSTWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYYSVPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQASMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |