Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2157 | 2157-30619 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75T, M184V, L210W, T215Y | K219DN | L100I, K103S | K102KR, V118I, K122KE, I142V, S162SN, T200TA, R211RK, V245T |
| >2157-30619| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKVTDFRELNKRTQDFWEVQLGIPHP AGIKRSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, G48GS, I54M, V82A, L90LM | L33F, K43T, F53L | L10I, G16E, E34Q, D60E, L63A, A71V, V77I, I93L |
| >2157-30619| codons 4-99 TLWQRPIVTIKIEGQLKEALLDTGADDTIFQEMNLPGRWTPKIVSGIGGLMKVRQYEQIA IEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |