Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2082 | 2082-30617 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219Q | K101DEHQ, Y181C, G190S | A98AG | E44ED, K66KR, T69N, K82KR, V118I, K122E, D123E, A158S, S162C, D177E, F214FL, D218E, L228H, V245VE |
| >2082-30617| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKRNSNRWRKVVDFRELNRRTQDFWEVQLGIPHP GGLQKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQCSMTKILEPFRKQNPEIVICQYMDDLYVSSDLEIGQHRTKIEELRQHLLRWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73T | I15V, K20I, E35ED, M36I, N37D, Q61H, I62V, L63P, A71I, I72IK, I85V, I93L |
| >2082-30617| codons 5-99 LWQRPFVTIKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYDHVPI EICGHKIKTTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |