<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2082 2082-30617 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L10F, G73T I15V, K20I, E35ED, M36I, N37D, Q61H, I62V, L63P, A71I, I72IK, I85V, I93L  
>2082-30617| codons 5-99
LWQRPFVTIKVGGQLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYDHVPI
EICGHKIKTTVLVGPTPVNVVGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, T215F K219Q K101DEHQ, Y181C, G190S A98AG E44ED, K66KR, T69N, K82KR, V118I, K122E, D123E, A158S, S162C, D177E, F214FL, D218E, L228H, V245VE  
>2082-30617| codons 38-247
CTELEKDGKISKIGPENPYNTPVFAIKKRNSNRWRKVVDFRELNRRTQDFWEVQLGIPHP
GGLQKKKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
SIFQCSMTKILEPFRKQNPEIVICQYMDDLYVSSDLEIGQHRTKIEELRQHLLRWGLFTP
EQKHQKEPPFHWMGYELHPDKWTVQPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006