Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1884 | 1884-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | G73T | L10I, I13V, K20I, R41RK, L63P, I64V, H69Q, I72R |
| >1884-30604| codons 4-99 TLWQRPIVTVKIGGQLIEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGFIKVRQYDQIP VEICGQKARTTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215FV | K219Q | K49Q, V60VI, V118I, I135T, A158AS, I178L, F214L, L228H, P243T, V245E |
| >1884-30604| codons 38-247 CTEMEKEGKISQIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP SIFQSSMTKILEPFRKQNPDLVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLVTP DQKHQKEPPFHWMGYELHPDKWTVQTIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |