Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1881 | 1881-30520 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54LV, V82A | L24I, L33F | L10I, T12P, K14R, K20KT, E35D, M36I, N37ND, R41K, L63P, A71T, I72V, N98ND |
| >1881-30520| codons 4-99 TLWQRPIVPIRIGGQLTEALIDTGADDTVFEDIDLPGKWKPKLIGGIGGFVKVRQYDQIP IEICGHKTVGTVLVGPTPANIIGRNLLTQIGCTLDF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, M184V, T215F | K219Q | K103N | K43N, K49KR, V60I, I135V, G196K, T200A, E203D, R211T, D218E, V245E |
| >1881-30520| codons 38-247 CTELENEGKISRIGPENPYNTPIFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIKQHRAKIDELRQHLLTWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |