Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1880 | 1880-40116 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 36 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | L33F, G73S | L10I, I13IV, E34Q, R41K, K55R, I62V, L63P, H69Y, A71G, I72R, V77I | R8Q |
| >1880-40116| codons 1-99 PQITLWQQPIVTVKIGGQLKEALLDTGADDTIFQEMNLPGKWKPKIVGGIGGFMRVRQYD QVPIEICGYKGRSTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, T215Y | D67G | L100I, K103N | V35T, S68G, D123E, D177E, G196E, E203K, Q207E, K223T, A272P, K277R, I293V, Q334N, G335D, G359S, K366R, A371V, Q394H, E396D |
| >1880-40116| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIKELREHLLRWGFYTPDKKHQTEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYARMRSA HTNDVRQLTEVVQKIATESIVIWGKTPKFKLPIHKDTWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |