Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1422 | 1422-30331 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54LV, V82VA, I84V | L24I, K43T | L10I, T12P, K14KR, I15V, K20R, R57K, D60E, L63P, I64V, P79PS |
| >1422-30331| codons 4-99 TLWQRPIVPIRVGGQLREALIDTGADDTVLEEMNLPGRWTPKIIGGIGGFVKVKQYEQIP VEICGHKAIGTVLVGSTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215F | K219Q | Y181C | A98G | K43E, T69N, R83K, K122P, I135T, I142V, I167IV, K173Q, I178L, G196E, I202V, D218E, V245E |
| >1422-30331| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSNRWRKVVDFRELNKKTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRQQNPDLVICQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |