Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1430 | 1430-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | G73S | L10I, I13V, Q18H, K20I, I62V, L63P, C67F, A71V, I72K, P79A |
| >1430-30317| codons 4-99 TLWQRPIVTVKIGGHLIEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVRQYDQVP IEIFGHKVKSTVLVGATPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215Y | K219N | V106A, G190A | F227L | T39TA, E44D, V118I, K122E, I202V, E203K, H208Y, L210S, K223E, D237DN |
| >1430-30317| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSATVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKVKELRQYLSRWGFYTP DNKHQEEPPLLWMGYELHPNKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |