Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1431 | 1431-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I54L, I84V, L90M | L33F, G73S | L10I, I13V, N37S, R41K, I62V, L63P, C67CFLW, G68E, A71V, I72M, V77I, I93L |
| >1431-30317| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMSLPGKWKPKLIGGIGGFLKVRQYDQVP IEIWEHKVMSTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215Y | K219E | A98G, V108I | D121Y, K122E, I135V, S162C, K173R, D177E, Q207E, H208Y, R211K, L228LH, P243PS |
| >1431-30317| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTILDVGDAYFSVPLYEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRRQNPEIVIYQYVDDLYVGSDLEIGQHRTKIEELREYLLKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQSIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |