Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1415 | 1415-30512 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46I, I54V, L90M | L10F, L33LI, Q58E, L76S, N88D | I13V, E34D, M36I, I62IV, L63P, A71T, I72V, I93L |
| >1415-30512| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADNTVIDEINLPGRWKPKIIGGIGGFVKVREYDQVP IEICGHKTVGTVSVGPTPVNIIGRDLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K219N | Y181C, P236L | T39A, K43E, E44A, F87L, V106I, V118I, K122E, I142V, S162Y, I178L, V179I, I195K, T200A, H208Y, R211K, W212M, K223Q, L228R |
| >1415-30512| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDLWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDLIICQYMDDLYVGSDLEKGQHRAKIEELRQYLWKMGFYTP DNKHQQEPPFRWMGYELHLDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |