Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1886 | 1886-30716 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | A98G | K43Q, E44D, T107TS, V118I, K122E, D123N, T200A, E203K, Q207DE, H208Y, R211K, K223E, L228H, V245E | N54I |
| >1886-30716| codons 38-247 CTELEQDGKISKIGPEIPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVSVLDVGDAYFSIPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP DRKHQEEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A, L90M | L10F, F53L, L89V | I13V, K20IV, M36I, L63P, H69KN, A71IV |
| >1886-30716| codons 4-99 TLWQRPFVTVKIGGQLVEALLDTGADDTILEEINLPGRWKPKIVGGIGGLIKVRQYDQIP IEICGNKVIGTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |