Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1405 | 1405-30501 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54IV, I84V, L90M | L10F, K43T | L19I, K20R, E35D, M36I, D60E, I62V, L63A |
| >1405-30501| codons 4-99 TLWQRPFVTIKIGGQIREALLDTGADDTVLEDINLPGRWTPKIIGGIGGFVKVRQYEQVA IEICGHKAIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, L210W, T215Y | K103N, Y181YC | K43E, K122P, I142IT, D177E, I178M, T200A, E203D, R211K, H221HY |
| >1405-30501| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDPDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEMVICQYMDDLYVGSDLEIGQHRAKIDELRQHLWKWGFYTP DKKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |