Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1404 | 1404-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | G73GS, T74P | L10I, R41K, K55R, I62V, L63P, C67CF, A71V, V77I, L89LM, I93L |
| >1404-30424| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIGGIGGFVRVRQYDQVP IEIFGHKVISPVLIGPTPVNVIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, T215Y | K219E | K103N | A98G, V108I | I94L, V118I, I142V, G196E, I202V, E203D, L210S, H221Y, V241I |
| >1404-30424| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKITDFRELNKRTQDFWEVQLGLPHP GGLKKNKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIEQHRTKVDELRQHLSRWGFYTP DEKYQKEPPFLWMGYELHPDKWTIQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |