Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2121 | 2121-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, V82A | L24I, K43T | L10I, L33M, L63P, K70T, A71V, I72T, T74A, I93L |
| >2121-30715| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTIMEEMNLPGRWTPKIIGGIGGFIKVRQYDQIP IEICGHTVTGAVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V | K219KQ | Y181C, G190A | K101KHNQ | I142IV, T200V, R211K, F214L, T216TP, H221Y | E53EK |
| >2121-30715| codons 38-247 CTEMEKEGKISKIGPKNPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRVKIEELRQHLLKWGLTPP DQKYQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |