Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2120 | 2120-40510 | U.S. | 2004 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 43 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219R | V106A, Y181C, G190A | T39A, E44D, V60I, K101Q, V118I, K122E, D123N, I135T, K173S, Q174K, V179I, T200A, Q207E, H208Y, R211K, H221C, V245Q |
| >2120-40510| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSATVLDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRSKNPDIIICQYMDDLYVASDLEIGQHRAKIEELREYLWKWGFYTP DRKCQKEPPFLWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, L90M | L10F, L33I, F53L, G73S, N88G, L89V | I13V, K14R, K20T, E35D, M36I, R41K, R57K, I62V, L63P, H69K, A71I |
| >2120-40510| codons 4-99 TLWQRPFVTVRIGGQLTEALLDTGADDTVIEDINLPGKWKPKIVGGIGGLIKVKQYDQVP IEICGKKIISTVLVGPTPVNIIGRGVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |