<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1778 1778-30605 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74IV, V75VAIT, M184MV, L210W, T215Y K219N Y181C, G190C   K43E, E44A, K101Q, V118I, K122E, S162SDGN, Q174K, V189I, E203D, Q207E, H208Y, R211K, L228H, V245VE  
>1778-30605| codons 38-247
CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKVTDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQNSMTKILEPFRKKNPDIVICQYVDDLYICSDLEIGQHRTKIDELREYLWKWGFYTP
DNKHQKEPPFHWMGYELHPDKWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46IL, I84V, L90M L10FI, V11I, L33F, G73S, L89V L5F, I13V, E34EQ, E35D, N37NS, I62IV, L63P, A71V, V77I, I93L  
>1778-30605| codons 4-99
TFWQRPIITVKIGGQLKEALLDTGADDTVFQDMSLPGRWKPKLIGGIGGFIKVRQYDQVP
IEICGHKVISTVLIGPTPVNVIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006