Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1778 | 1778-30605 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74IV, V75VAIT, M184MV, L210W, T215Y | K219N | Y181C, G190C | K43E, E44A, K101Q, V118I, K122E, S162SDGN, Q174K, V189I, E203D, Q207E, H208Y, R211K, L228H, V245VE |
| >1778-30605| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKVTDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKKNPDIVICQYVDDLYICSDLEIGQHRTKIDELREYLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46IL, I84V, L90M | L10FI, V11I, L33F, G73S, L89V | L5F, I13V, E34EQ, E35D, N37NS, I62IV, L63P, A71V, V77I, I93L |
| >1778-30605| codons 4-99 TFWQRPIITVKIGGQLKEALLDTGADDTVFQDMSLPGRWKPKLIGGIGGFIKVRQYDQVP IEICGHKVISTVLIGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |