Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1779 | 1779-30605 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, Q58E, G73S | T12K, I13V, L19LP, K20I, E35D, M36I, K55R, I62V, L63P, A71T, I72T, T91S |
| >1779-30605| codons 4-99 TLWQRPFIKVKIGGQPIEALLDTGADDTVLEDINLPGRWKPKIIGGIGGFVRVREYDQVP IEICGHKTTSTVLVGPTPVNVIGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K103S, V106A, G190A | F227L | K43Q, E44D, L109I, V118I, K122E, V179I, G196E, T200AE, E203K, Q207E, H208Y, R211K, H221Y, V245Q |
| >1779-30605| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKSKSATVIDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLYVASDLEIEQHREKIKELREYLWKWGFYTP DKKYQKEPPLLWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |