Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1777 | 1777-30602 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | K43T, F53L | L10I, I15V, K20R, E35ED, M36I, R41K, L63P, A71V, I85V |
| >1777-30602| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTILEDINLPGKWTPKIIGGIGGLVKVRQYDQIP IEICGHKVIGTVLVGPTPANIVGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | K103KN, Y188L | I94IL, K102X, V118I, K122E, I135T, V179I, Q197E, I202V, F214L, V245K |
| >1777-30602| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGLPHP AGLKXNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYVDDLLVGSDLEIGEHRTKVEELRQHLLRWGLFTP DQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |