Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1775 | 1775-30509 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V | L10I, I15V, K20R, M36I, I62V, L63P, L89LM |
| >1775-30509| codons 4-99 TLWQRPIVTIKVGGQLREALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKAIGTVVVGPTPVNVIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70KR, L74LIV, M184V, T215F | V75VL, K219Q | K103N | V108I | V60I, K102G, K122E, D123E, I135T, S162A, H208HY, K223T, L228H, V245Q |
| >1775-30509| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKVLDFRELNKRTQDFWEVQLGIPHP AGLKGNKSVTILDVGDAYFSVPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQYLLRWGFFTP DQKHQTEPPFHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |