Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1126 | 1126-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, L90M | L10F, L33F, F53L | I13V, I15V, K20R, M36IL, R41K, I62V, L63P, I66F, A71V, I72L |
| >1126-30417| codons 4-99 TLWQRPFVTVKVGGQLREALLDTGADDTIFEELNLPGKWKPKIVGGIGGLLKVRQYDQVP IEFCGHKVLGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74I, M184V | T215V, K219Q | K103N | V108I, P225H | S48T, K122E, I135M, S162C, T200A, L228V, V245Q |
| >1126-30417| codons 39-247 TEMEKEGKITKIGPENPYNTPVFAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPA GLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPA IFQCSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFVTPD QKHQKEHPFVWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |