Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1125 | 1125-30328 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75T, T215F | K219E | Y181I | T39A, S48T, T69N, K122E, I135L, T200A, E203D, K223E, L228H |
| >1125-30328| codons 38-247 CAELEKEGKITKIGPENPYNTPVFAIKKKNSNRWRKLTDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIIQYMDDLYVGSDLEIGQHRAKIDELRQHLLRWGFFTP DEKHQEEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, L90M | L10I, K20R, E35D, M36I, N37AE, I62V, L63P, A71V, I85V, Q92K |
| >1125-30328| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEDIELPGRWKPKIIGGVGGFVKVRQYDQVP IEICGHKVIGTVLVGPTPVNIVGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |