Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1123 | 1123-30313 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215Y | K219E | K103N | V108I | T39A, E44D, V118I, K122E, D123N, I135T, I178IL, T200A, E203D, L205F, H208Y, R211K, H221HY, K223Q, L228H |
| >1123-30313| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVIYQYVDDLYVGSDLEIGQHRAKIDEFRQYLLKWGFYTP DEKYQQEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82A, I84V | L24I, L33F | L10I, T12K, I13V, Q18H, E35D, M36MIL, N37D, I62IV, L63P, I66F, C67CY, A71V, V77VI, T91S |
| >1123-30313| codons 4-99 TLWQRPIVKVKIGGHLKEALIDTGADDTVFEDLDLPGRWKPKIIGGIGGFAKVRQYDQVP IEFYGHKVIGTVLIGPTPANVIGRNLLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |