Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1115 | 1115-30304 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | K103N, Y181C, G190GA | V108VI | T39A, E44D, V90VI, V118I, I142T, K166R, K173Q, T200TA, R211K, L228R, V245VE |
| >1115-30304| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKDSDKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKNKSVTILDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSP AIFQSSMTRILEPFRQQNPDIVICQYMDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTP DRKHQKEPPFRWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54A, V82A | K43T | L10I, I62V, L63P, I64V, A71AV, V77I, I93IL |
| >1115-30304| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKMIVGIGGFAKVRQYDQVP VEICGHKVIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |