Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1402 | 1402-30702 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215F | K219E | Y181C, G190S | T39A, E44D, V60I, K101Q, V118I, K122E, E203D, H208Y, R211K, D218E, L228H, Q242H |
| >1402-30702| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVSSDLEIGQHRTKIDELRQYLWKWGFFTP EEKHQKEPPFHWMGYELHPDKWTVHPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, L90M | K43T, G73S, L89V | L10I, V11L, I13V, L19I, K20R, E35D, M36I, N37H, L63P, A71I, I72E, V77I, V82I, I93L |
| >1402-30702| codons 4-99 TLWQRPILTVKIGGQIREALLDTGADDTILEDIHLPGRWTPKIVGGIGGFMKVRQYDQIP IEICGHKIESTVLIGPTPINIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |