Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1400 | 1400-30626 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33F, Q58E | K20MR, I62V, L63P, I64M, C67F, A71V, I72T, V77I, T91S, Q92R, I93L |
| >1400-30626| codons 4-99 TLWQRPLVTIKIGGQLREALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVREYDQVP MEIFGHKVTGTVLIGPTPVNVIGRNLMSRLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K219Q | A98G | K43M, E44D, V60I, V118I, K122E, D123N, I135L, I142V, Q197P, H208Y, R211K, D218E, L228H, V245E |
| >1400-30626| codons 38-247 CTELEMDGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSLNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGPHRTKIEELRQYLWKWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |