Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1401 | 1401-30626 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82A | L10FI, L24I, L33F, K43T | T12P, K14R, E35D, M36L, K55R, Y59YF, I62IV, L63P, A71T, I72T, V77VI, T91S |
| >1401-30626| codons 4-99 TLWQRPIVPIRIGGQLKEALIDTGADDTIFEDLNLPGRWTPKIVGGIGGFIRVRQFDQVP IEICGHKTTGTVLIGPTPANIIGRNLLSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, T215Y | D67G, K219D | T39A, E44D, S68G, L100LF, D123E, I135L, D177E, I178L, T200A, I202V, E203K, K223E, E224D, L228H, V245I |
| >1401-30626| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKGGTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGFKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIYQYVDDLYVGSDLEIGQHRAKVKELRQHLLRWGFYTP DDKHQEDPPFHWMGYELHPDKWTVQPIILP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |