Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1399 | 1399-30625 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N, Y181C | T39E, E44D, K64R, V118I, K122E, I135T, I142V, G196E, T200A, E203K, Q207E, H208Y, R211K, K223Q, L228H |
| >1399-30625| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIEQHRAKIKELREYLWKWGFYTP DNKHQQEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54V, V82A | L33I, K43T | L10I, T12P, I13V, K20R, E35D, M36L, Q61E, I62V, L63P, I64V, A71T, V77I |
| >1399-30625| codons 4-99 TLWQRPIVPVKIGGQLREALLDTGADDTVIEDLNLPGRWTPKMIVGVGGFVKVRQYDEVP VEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |