<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1398 1398-31001 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 14

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y   Y181C, G190A K101H K20R, V35L, T39A, K43E, E44D, S48T, V118I, S162Y, V179I, I195KR, G196E, E203K, H208Y, R211K, W212M, K223E, F227Y, A272P, V276T, K277R, L283I, I293V, I329L, R356K, M357V, K366R, T369V, K374R, I375V, S379C, K390R  
>1398-31001| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEDGKITKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII
CQYVDDLYVASDLEREQHRTKIKELRQYLWKMGFYTPDKKHQEEPPYLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKVRGA
HTNDVRQLVEAVQRVATECIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82C, L90M L33F, F53L, Q58E, G73A L10IV, L19I, E34T, K55KR, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L  
>1398-31001| codons 1-99
PQITLWQRPVVTIKIGGQIKEALLDTGADDTVFTEMNLPGRWKPKIVGGIGGLVRVREYD
HVPIEIWGHKTEATVLIGPTPCNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006