Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1398 | 1398-31001 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 14 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | Y181C, G190A | K101H | K20R, V35L, T39A, K43E, E44D, S48T, V118I, S162Y, V179I, I195KR, G196E, E203K, H208Y, R211K, W212M, K223E, F227Y, A272P, V276T, K277R, L283I, I293V, I329L, R356K, M357V, K366R, T369V, K374R, I375V, S379C, K390R |
| >1398-31001| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEEDGKITKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII CQYVDDLYVASDLEREQHRTKIKELRQYLWKMGFYTPDKKHQEEPPYLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYAKVRGA HTNDVRQLVEAVQRVATECIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82C, L90M | L33F, F53L, Q58E, G73A | L10IV, L19I, E34T, K55KR, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L |
| >1398-31001| codons 1-99 PQITLWQRPVVTIKIGGQIKEALLDTGADDTVFTEMNLPGRWKPKIVGGIGGLVRVREYD HVPIEIWGHKTEATVLIGPTPCNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |