Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1398 | 1398-30623 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82C, L90M | L33F, F53L, Q58E, G73A | L10I, L19I, E34T, Q61H, I62V, L63P, C67W, A71T, I72E, V77I, I93L |
| >1398-30623| codons 4-99 TLWQRPIVTIKIGGQIKEALLDTGADDTVFTEMNLPGRWKPKIVGGIGGLVKVREYDHVP IEIWGHKTEATVLIGPTPCNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | Y181YC, G190A | K101H | T39A, K43E, E44D, S48T, V118I, E138EA, S162CY, V179VI, E194EQ, I195IR, G196GE, E203K, H208Y, R211K, W212M, K223E, F227Y, L228LF |
| >1398-30623| codons 38-247 CAELEEDGKITKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIIICQYVDDLYVASDLQREQHRTKIKELRQYLWKMGFYTP DKKHQEEPPYFWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |