Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1014 | 1014-30324 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90M | N88D | I13V, K20KR, E35D, M36I, N37S, R57K, I62V, L63P, A71T |
| >1014-30324| codons 4-99 TLWQRPLVTVKIGGQLREALLDTGADNTVLEDISLPGRWKPKMIGGIGGFIKVKQYDQVP IEICGHKTIGTVLVGPTPVNIIGRDLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | D67G, T215I, K219E | Y181I | S68G, K122E, I135V, I142L, Y144F, K173Q, I202V, F214L |
| >1014-30324| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGLRFQYNVLPQGWKGSP AIFQSSMTKILEPFRQQNPDIVIIQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLITP DEKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |