Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1911 | 1911-30514 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, V11I, L33F, Q58E, G73S | I13V, G16GA, E34Q, G51A, L63P, A71V |
| >1911-30514| codons 4-99 TLWQRPFITVKIAGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIAGFVKVREYDQIP IEICGHKVISTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, V75T, M184V, L210LW, T215F | D67G, K219E | K103N, Y181C | T39A, S68G, V118I, I135L, S162D, Q174H, V179VI, T200L, H208Y, R211K, D218E, L228H, V241I |
| >1911-30514| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKGGTRWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKHNPDIIICQYVDDLYVGSDLEIGQHRLKIEELRQYLWKWGFFTP EEKHQKEPPFHWMGYELHPDKWTIQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |