<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1912 1912-30514 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10F, V11I, L33LF, G73S, L89V I15V, K20V, E35D, M36I, R57K, L63P, A71V, I72FL, P79A, I85V  
>1912-30514| codons 4-99
TLWQRPFITIKVGGQLVEALLDTGADDTVFEDINLPGRWKPKMIGGIGGFVKVKQYDQIP
IEICGHKVLSTVLVGATPVNVVGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, T215F K219Q K101E, Y181C, G190A V108I T39TA, K43Q, K49R, V60I, T69N, K122E, D123DN, I135IT, S162D, S163T, E169D, Q174R, I178M, V179I, G196E, T200A, E203Q, Q207E, D218E, V245K  
>1912-30514| codons 38-247
CAELEQEGKISRIGPENPYNTPIFAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP
AGLEKKKSVTILDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQDTMTKILDPFRKRNPDMIICQYVDDLYVASDLEIEQHRAKIQELREHLLRWGFFTP
EQKHQKEPPFLWMGYELHPDKWTVQPIKLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006