Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1912 | 1912-30514 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, V11I, L33LF, G73S, L89V | I15V, K20V, E35D, M36I, R57K, L63P, A71V, I72FL, P79A, I85V |
| >1912-30514| codons 4-99 TLWQRPFITIKVGGQLVEALLDTGADDTVFEDINLPGRWKPKMIGGIGGFVKVKQYDQIP IEICGHKVLSTVLVGATPVNVVGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | K101E, Y181C, G190A | V108I | T39TA, K43Q, K49R, V60I, T69N, K122E, D123DN, I135IT, S162D, S163T, E169D, Q174R, I178M, V179I, G196E, T200A, E203Q, Q207E, D218E, V245K |
| >1912-30514| codons 38-247 CAELEQEGKISRIGPENPYNTPIFAIKKKNSNRWRKIVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAYFSVPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQDTMTKILDPFRKRNPDMIICQYVDDLYVASDLEIEQHRAKIQELREHLLRWGFFTP EQKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |