Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1114 | 1114-30509 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L33F, G73T | L10I, K20R, E34EV, E35D, M36I, R41K, I62V, L63P, A71I, V77VI, I93L |
| >1114-30509| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVFVDINLPGKWKPKMIGGIGGFLKVRQYDQVP IEICGHKIITTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Y115F, Q151M | A62V, V75I, F77L, F116Y, K219E | Y181I | T39TA, S68G, V118I, K122E, K166R, I202V, R211RK, F214L |
| >1114-30509| codons 38-246 CAEMEKEGKISKIGPENPYNTPVFVIKRKDGTRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAFYSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTRILEPFRKQNPDIVIIQYMDDLYVGSDLEIGQHRTKVEELRQHLLKWGLTTP DEKHQKEPPFLWMGYELHPDKWTVQPIVL |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |