Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2425 | 2425-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V | L24I | L10I, E35D, M36I, N37E, L63P, A71V, I72V, V77I, I93L |
| >2425-30820| codons 4-99 TLWQRPIVTIKIGGQLKEALIDTGADDTVLEDIELPGRWKPKIIGGIGGFVKVRQYDQIP IEICGHKVVGTVLIGPTPANVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | Y181C, G190A | E40F, K43EQ, K101Q, V111I, K122E, T165I, D177E, I178L, G196E, T200A, Q207E, R211K |
| >2425-30820| codons 38-247 CTFLEQEGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDIGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPELVICQYMDDLYVASDLEIEQHRAKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |