Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2423 | 2423-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50V, I54S, V82A | L33F | L10V, I13V, E34Q, L63P, A71V, I72V, V77I, I93L |
| >2423-30820| codons 4-99 TLWQRPVVTVKIGGQLKEALLDTGADDTVFQEMNLPGRWKPKMIVGVGGFSKVRQYDQIP IEICGHKVVGTVLIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184MV, T215Y | Y181C, G190A | K122E, D123DN, I135IV, K173E, L228R, V245E |
| >2423-30820| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFREQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQHLLRWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |