Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2485 | 2485-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54L, V82A, L90M | L33F, F53L, Q58E, L89LV | L10I, I13V, K14R, I15V, M36L, L38W, R41K, K55R, D60E, Q61E, I62V, L63P, K70KE, A71V |
| >2485-30821| codons 4-99 TLWQRPIVTVRVGGQLKEALLDTGADDTVFEELNWPGKWKPKIVGGIGGLLRVREYEEVP IEICGHEVIGTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, M184V, L210W, T215Y | K219R | K103N | E40D, E44G, K49R, V60I, V118I, K122E, I135M, V179VI, R211RK, K223Q, L228R | M41F, E42R |
| >2485-30821| codons 39-247 TDFRKGGKISRIGPENPYNTPIFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPA GLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPA IFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPD RKHQQEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |