<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2485 2485-30821 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54L, V82A, L90M L33F, F53L, Q58E, L89LV L10I, I13V, K14R, I15V, M36L, L38W, R41K, K55R, D60E, Q61E, I62V, L63P, K70KE, A71V  
>2485-30821| codons 4-99
TLWQRPIVTVRVGGQLKEALLDTGADDTVFEELNWPGKWKPKIVGGIGGLLRVREYEEVP
IEICGHEVIGTVLVGPTPANIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
T69D, M184V, L210W, T215Y K219R K103N   E40D, E44G, K49R, V60I, V118I, K122E, I135M, V179VI, R211RK, K223Q, L228R M41F, E42R
>2485-30821| codons 39-247
TDFRKGGKISRIGPENPYNTPIFAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPA
GLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPA
IFQSSMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTPD
RKHQQEPPFRWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006