Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2136 | 2136-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L10F, L33F, N83D | K20R, E35D, M36L, R41K, K45V, K55Q, I62V, L63P, I64V |
| >2136-30821| codons 4-99 TLWQRPFVTIKIGGQLREALLDTGADDTVFEDLNLPGKWKPVLIGGIGGFVQVRQYDQVP VEICGHKAIGTVLVGPTPVDVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K101PQ, Y181C, G190A | V108VI, V179VF | T39TA, E40F, K43E, K103KR, V118I, K122E, Q174R, T200A, L205F, H208Y, R211K, V245I |
| >2136-30821| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKRKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPDIFICQYVDDLYVASDLEIGQHRAKIEEFRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIILP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |