Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2133 | 2133-30820 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48M, I50V, I54V, V82A, L90M | L33F, F53L | L10I, I13M, L19I, E34Q, I62V, L63H, I64M, H69Q, A71V, V77I, T91S, I93L, C95F |
| >2133-30820| codons 4-99 TLWQRPIVTMKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKMIMGVGGLVKVRQYDQVH MEICGQKVIGTVLIGPTPANIIGRNLMSQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K101P, Y188L | K43Q, E44D, V118I, K122E, Q207E, L228H |
| >2133-30820| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLPKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLLVGSDLEIGQHRTKIEELREHLWRWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |