Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2131 | 2131-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, T215Y | K219Q | K103N, Y181C | T39A, E44K, E53Q, V60I, I135L, I178M, Q207AT, H208Y, R211K, H221Y, L228H, V245Q | N57K |
| >2131-30813| codons 38-247 CAELEKKGKISKIGPQNPYKTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVICQYMDDLYVGSDLEIGQHRTKIEELRTYLLKWGFYTP DQKYQKEPPFHWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, L90M | E35D, N37D, K55R, R57K, I62V, L63P, A71V, I93L |
| >2131-30813| codons 4-99 TLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIRVKQYDQVP IEICGHKVIGTVVVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |