Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3099 | 3099-30606 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, L210W, T215Y | K219E | K103NS, Y181C, G190A | E44D, V60I, K101Q, V118I, K122E, D177E, H208Y, R211K, D218E, L228R |
| >3099-30606| codons 38-247 CTELEKDGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP AGLQKSKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYMDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTP EEKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54L, V82A, I84V, L90M | L33F, G73T | L10I, K55R, D60E, I62V, L63P, C67F, H69R, K70T, A71V, I72T |
| >3099-30606| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFLRVRQYEQVP IEIFGRTVTTTVLVGPTPANVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |