Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3197 | 3197-40128 | Canada | 2004 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 23 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69D, K70R, M184MV, T215F | D67G | V179E | T39A, V60I, S68SG, K122KE, E138A, T139TM, S162A, K173T, Q174K, N175Y, Y181X, T200A, Q207E, R211K, F214L, H221HY, V245Q |
| >3197-40128| codons 38-247 CAEMEKEGKISKIGPENPYNTPIFAIKKKGGDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNAMPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRTKYPDIEIXQYVDDLYVGSDLEIGQHRAKIEELREHLLKWGLFTP DKKYQKEPPFLWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L89V | L10V, I13A, K14R, K20I, A22V, L33L_L, M36I, R41K, I62V, H69K, G73D, T74S, T91TS |
| >3197-40128| codons 4-99 TLWQRPVVTARIGGQLIEVLLDTGADDTVLEEINLPGKWKPKMIGGIGGFVKVRQYDQVL IEICGKKAIDSVLVGPTPANIIGRNVLSQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |