Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-3048 | 3048-30429 | Canada | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, V82T, I84V, L90M | L33F | L10I, I13V, K55R, I62V, L63P, K70E, A71V, Q92R |
| >3048-30429| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFLRVRQYDQVP IEICGHEVIGTVLVGPTPTNVIGRNLMTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69GS_X, T215Y | K64R, R83K, I178IL, G196K, Q207E | L228HY |
| >3048-30429| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIRKKDSSKWRKLVDFRELNKKTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLVIYQYMDDLYVGSDLEIKQHRTKIEELREHLLRWGFYTP DKKHQKEPPFYWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |